The suppression of important WT1 isoform-mediated transcriptional activation by Ex4a(+) WT1 may be extended to other immediate transcriptional targets as well as Bcl-xL and Bcl-2. Given that some other genes liable for anti-apoptosis these as BFL-1 and c-myc have already been also identified as direct transcriptional targets of big WT1 isoforms [16, 17], Ex4a(+)WT1-induced apoptosis is likely to b


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