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The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory area but lacked the zinc finger DNA-binding domain, and therefore the truncated Ex4a(+)WT1 isoform retained the opportunity to connect with the transcriptional co-activators but missing the ability to bind to promoter of downstream targets. Preceding experiments have proven the N-terminal domainPLOS One

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