On top of that, the reduction in Dox-induced apoptosis by Ex4a-specific siRNAs was cancelled by concomitant compelled overexpression of Ex4a(+)WT1 isoform. These final results indicated that endogenous Ex4a(+)WT1 had a physiological purpose to promote apoptosis.DiscussionThe WT1 gene creates 4 significant isoforms by different splicing of exon 5 (17AA) and exon 9 (KTS). All 4 big isoforms are over


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