On top of that, the reduction in Dox-induced apoptosis by Ex4a-specific siRNAs was cancelled by concomitant compelled overexpression of Ex4a(+)WT1 isoform. These final results indicated that endogenous Ex4a(+)WT1 experienced a physiological functionality to promote apoptosis.DiscussionThe WT1 gene provides four main isoforms by substitute splicing of exon 5 (17AA) and exon 9 (KTS). All four signif


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